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White Dwarf 2p

Laser for 2-photon high-speed volumetric imaging
  • wavelength: 920 nm or 960 nm
  • high average power: > 2 W or  > 4 W
  • high repetition rate: 10 MHz
  • suitable for 2-photon high-speed volumetric imaging
  • based on industrial grade Yb-based femtosecond laser

Introduction

High performance femtosecond laser for two-photon microscopy (2p microscopy)

The White Dwarf is a femtosecond laser system specially designed for multi-photon microscopy offering highest performance and robustness.

With the highest peak power available for 2-photon microscopy, the White Dwarf allows neuroscientists to exploit advanced multiplexing techniques to image larger volumes at higher speeds. Additionally, the one-box solution offers compactness and robustness.

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Features

High power for multiplexing 2-photon imaging

> 4 W average power after compressor at 10 MHz

Proven in the field

Trusted by 20+ neuroscience labs worldwide

Reliability

Robust one-box design

1035 nm output

Output for optogenetics optionally available

Specs

WD-920 WD-920-pro WD-960 WD-960-pro
Central wavelength 920 nm 920 nm 960 nm 960 nm
Average power > 2 W > 4 W > 2 W > 4 W
Pulse duration FWHM < 100 fs < 100 fs < 100 fs < 100 fs
Dispersion compensation optionally up to -20.000 fs^2 optionally up to -20.000 fs^2 optionally up to -20.000 fs^2 optionally up to -20.000 fs^2
Pulse energy compressed > 200 nJ > 400 nJ > 200 nJ > 400 nJ
Repetition rate 10 MHz 10 MHz 10 MHz 10 MHz
Beam quality M2 < 1.3 < 1.3 < 1.3 < 1.3
Power stability
12 hrs
< 1 % < 1 % < 1 % < 1 %
Dimensions 95 cm x 65 cm 95 cm x 65 cm 95 cm x 65 cm 95 cm x 65 cm


Applications

  • Volumetric brain imaging
  • Light beads microscopy (LBM) and multi-plexed microscopy
  • Scanning temporal focusing microscopy (sTeFo)


FAQ

Do you have customer references?

Yes, the White Dwarf is already installed and tested by many labs. Please contact us, we are happy to share specific references to your application. You can find a first overview of scientific publications from our users below.

How many outputs does the White Dwarf 2p provide?

The White Dwarf 2p can offer up to two outputs: 960 nm and 1035 nm. The system can be designed to offer all outputs simultaneously or switchable between different outputs. Please contact us for customization options.

At which repetition rate does the White Dwarf 2p operate?

Our White Dwarf 2p version can be configured at any single repetition rate between 1 and 10 MHz. The maximum average power is available at the configured repetition rate. Lower repetition rates can be chosen using the built-in pulse-picker. This provides a constant pulse energy at correspondingly lower average power. Example: WhiteDwarf operating at 5 MHz and 1 µJ delivers 5 W; it can be down-picked to 2 MHz and 1 µJ delivering 2 W.

Who installs the White Dwarf?

Our service team will install the pump laser and the OPCPA at the customer’s site. Users will receive training on the operation of the White Dwarf.

Is the pump laser included in the White Dwarf?

Yes, we offer the full package including pump laser and OPCPA. The pump laser is integrated into the OPCPA housing on a shared thermally managed breadboard offering a robust one-box solution.


Publications

  • August 30, 2021
    Demas, J., Manley, J., Tejera, F. et al. High-speed, cortex-wide volumetric recording of neuroactivity at cellular resolution using light beads microscopy. Nat Methods (2021).
  • May 2, 2019
    Weisenburger et al., Volumetric Ca2+ Imaging in the Mouse Brain Using Hybrid Multiplexed Sculpted Light Microscopy, Cell (2019)
  • September 30, 2021
    Streich, L., Boffi, J.C., Wang, L. et al. High-resolution structural and functional deep brain imaging using adaptive optics three-photon microscopy. Nat Methods 18, 1253–1258 (2021).
  • January 16, 2024
    Jason Manley, Jeffrey Demas, Hyewon Kim, Francisca Martínez Traub, Alipasha Vaziri, Simultaneous, cortex-wide and cellular-resolution neuronal population dynamics reveal an unbounded scaling of dimensionality with neuron number, bioRxiv 2024