A new microscopy approach developed by the Vaziri Lab at Rockefeller University takes the next steps for high-speed, volumetric recording of neuroactivity in the mouse cortex. The developed so called Light Beads Microscopy (LBM) is a mesoscopic imaging approach able to record up to 1 million neurons within 5.4×6×0.5 mm^3 volumes at 2 Hz frame rate.
Hence, the technology can enable neuroscientists to understand cortex-wide information processing and ultimately how the brain works.
Measurements have been performed with the White Dwarf OPCPA for 3-photon microscopy.
Reference: Demas, J., Manley, J., Tejera, F. et al. High-speed, cortex-wide volumetric recording of neuroactivity at cellular resolution using light beads microscopy. Nat Methods (2021). https://doi.org/10.1038/s41592-021-01239-8