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Intelligent Imaging Innovations (3i) and Class 5 Photonics host a joint webinar about "Imaging mouse brain activity with sculpted light using VIVO multiphoton scanned temporal focusing".
Place: Zoom webinar Time: Thursday 3rd November, 9 am PDT / 12 pm EDT / 17h CET
During the webinar you will learn about scanned temporal focusing (sTeFo) and its benefits for imaging mouse brain activity. Professor Alipasha Vaziri will introduce the technology and show examples how with sTeFo you can image large neural networks in the mouse brain. 3i presents the combination of sTeFo with its multiphoton microscopes. Class 5 Photonics presents how the White Dwarf laser system is optimally designed to tackle the demands of sTeFo.
We are honored to give an invited talk at CLEO conference. Our CEO Robert will present remotely a review of our high-power, ultrafast OPCPA systems on Monday:
You can also meet us in person at our booth #415 or join our other talks:
Meet us in Paris at OPTOGEN2022 and join our product talk. The 7th International Workshop on Technologies for Optogenetics and Neurophotonics will take place in Paris, France, on May 11-13, 2022. OPTOGEN2022 brings together the most active scientists and technologists to discuss recent progresses and future challenges in technologies for in vivo optogenetics and optical neural interfaces.
Class 5 Photonics will be at the High-Brightness Sources and Light-Driven Interaction Congress in Budapest, Hungary from 23rd to 25th March 2022.
Meet us at our booth and join the talk of our project leader Dr. Torsten Golz about the the ELI-ALPS MIR-HE Laser System - Design and Status (MTh5C.3) on 24 March 15:15 - 15:30h. The ultimate goal of Class 5 Photonics and ELI-ALPS is to generate via higher harmonic generation (HHG) attosecond pulses with a wavelength shorter than 1 nm at 1 kHz operation. In order to reach such extreme light properties a new high-energy mid-infrared laser system is being developed by Class 5 Photonics. This MIR-HE laser is an optical parametric chirped-pulse amplifier (OPCPA), a method to generate ultrashort pulses at different wavelengths and the specialty of the Class 5 Photonics team for more than ten years. The final output specifications of the MIR-HE laser are 3 μm wavelength, 20 mJ pulse energy, 1 kHz pulse repetition rate and 25 fs pulse duration with stable carrier-envelope phase (CEP). 
Active carrier envelope phase (CEP) stabilization in the few-cycle regime is essential for most attosecond experiments. We present an optical parametric chirped-pulse amplifier (OPCPA) design providing CEP stable, sub 9 fs pulses with a dual channel output around 800 nm center wavelength and 2 µm as a high-harmonic driver for attosecond experiments.
The system is commercially available as White Dwarf OPCPA. Our project leader Katja presents a scientific talk about this system at "DPG-Frühjahrstagung der Sektionen Atome, Moleküle, Quantenoptik und Photonik" (DPG SAMOP). Join us on Tuesday 10.45 am. 
The Central Innovation Program for SMEs (ZIM) by the German Federal Ministry of Economics and Technology (BMWi) will fund a development project for a high-performance laser to be developed by DESY and the start-up Class 5 Photonics starting January 2022. The goal of the collaboration is to develop a high-performance laser with ultrashort x-ray pulses that can be used as a measuring instrument in quality assurance.
SPIE Photonics West is around the corner and Class 5 Photonics will be present in person to engage with you. You can meet us directly at our booth in the German Pavillon A #4429-17 and discuss with our experts on few-cycle lasers and lasers for multi-photon microscopy. Additionally, we have two exciting talks showing our latest results. Especially, don't miss our talk about the MIR-HE project at ELI-Alps, which will provide extreme power at 3 µm for higher harmonic generation in the XUV.
Talks:
Sometimes great success starts with humble ideas – how to make a small laser from a super-high-power technology?
Inspired by cutting-edge neuroscientists, and developed to its best - we are very honored that our White Dwarf OPCPA is nominated as finalist for the SPIE Prism awards 2022. This prestigious, international award honors the best new optics and photonics products on the market. We congratulate all finalists. Looking forward to see you in San Francisco on 26 January 2022. 
Re-watch our great product video discussing the White Dwarf and its benefits for neuroscience and three-photon microscopy. We hope many more biologists and neuroscientists will benefit from our technology, and will ultimately advance neurobiology and our understanding of brain functionalities and diseases.
A new microscopy technique developed at EMBL in Heidelberg enables highest imaging resolution for in vivo neuronal activity measurements deep in the brain, driven by a Class 5 Photonics White Dwarf OPCPA. Indirect adaptive optics (AO) in combination with three-photon microscopy reaches near-diffraction-limited resolution of very fine structures in the hippocampus up to a depth of 1.4 mm.
Chat with our experts about three-photon microscopy and register for our product demo presented by our Sales manager Luisa at virtual Neuroscience on 11th November 7.30-8.30 am CT / 14.30-15.30 h CET! A recording will be available later. Please, register for access to the recording.
We are at the virtual "Jahrestagung der DPG und DPG-Tagung der Sektion Kondensierte Materie (SKM)"9/20/2021
Visit out interactive online booth and get in touch with us at "Jahrestagung der DPG und DPG-Tagung der Sektion Kondensierte Materie (SKM)".
At the "Science meets Industry" session on Wednesday afternoon our CEO Robert will present a talk about "Basics and concepts of optical parametric chirped-pulse amplification (OPCPA)". Meet you there! 
Light Beads Microscopy (LBM) with the White Dwarf OPCPA for high-speed, volumetric brain imaging9/6/2021
A new microscopy approach developed by the Vaziri Lab at Rockefeller University takes the next steps for high-speed, volumetric recording of neuroactivity in the mouse cortex. The developed so called Light Beads Microscopy (LBM) is a mesoscopic imaging approach able to record up to 1 million neurons within 5.4×6×0.5 mm^3 volumes at 2 Hz frame rate.
Hence, the technology can enable neuroscientists to understand cortex-wide information processing and ultimately how the brain works. Measurements have been performed with the White Dwarf OPCPA for multi-photon microscopy. Reference: Demas, J., Manley, J., Tejera, F. et al. High-speed, cortex-wide volumetric recording of neuroactivity at cellular resolution using light beads microscopy. Nat Methods (2021). https://doi.org/10.1038/s41592-021-01239-8
The Extreme Light Infrastructure Attosecond Light Pulse Source (ELI ALPS) in Szeged, Hungary and Class 5 Photonics have signed a research and development contract for the new Mid-Infrared High-Energy (MIR-HE) laser and attosecond beamline (MIR-HE ATTO) at ELI ALPS.
ELI ALPS is a research facility providing cutting-edge laser systems and secondary sources for worldwide users. The focus of the institution is on so-called attosecond light pulses, an extreme form of laser light with two remarkable properties: These light pulses have a wavelength typically in the extreme ultraviolet region from 10 - 100 nm, thus allowing observations of nanometer scale objects. Further, the short light flashes have such extraordinarily short duration that even the motion of electrons can be captured (1 attosecond = 0.000000000000000001 seconds).
With the MIR-HE ATTO source, Class 5 Photonics and ELI want to take the technology one step further: Current sources are limited in the available power and the ultimately accessible wavelength. For the first time, attosecond pulses with a wavelength shorter than 1 nm will be generated. “This project is an outstanding opportunity for Class 5 Photonics and totally within the DNA of our team.” says Dr. Torsten Golz, who is leading the project at Class 5 Photonics.
In order to reach such remarkable light properties 1000 times per second (1 kHz) a new high-energy mid-infrared laser system is being developed by Class 5 Photonics. The MIR-HE laser is an optical parametric chirped-pulse amplifier (OPCPA), a method to generate ultrashort pulses at different wavelengths and the specialty of the Class 5 Photonics team for more than ten years. The MIR-HE laser system will additionally comprise the most advanced laser technologies, such as spectral phase-shapers, adaptive mirrors, and nonlinear spectral broadening. One of the key components is a high-power picosecond thin-disk laser provided by Trumpf Scientific Lasers in Munich, Germany, which delivers 200 mJ pulse energy at 1 kHz repetition rate. The final output specifications of the MIR-HE laser are 3 μm wavelength, 20 mJ pulse energy, 1 kHz pulse repetition rate and 25 fs pulse duration with stable carrier-envelope phase (CEP). The intense mid-infrared pulses from the MIR-HE laser will be focused in a high-density gas target, specially developed by Class 5 Photonics. Here, the infrared laser pulses will be converted to soft X-ray pulses with photon energies exceeding 1 keV, corresponding to wavelengths below 1 nm. The physical process is called higher-harmonic generation (HHG). Class 5 Photonics has a team of experts who are experienced in highest power laser development and extreme ultraviolet to soft X-ray generation. Within the next two years, the team will develop not only the MIR-HE laser and the MIR-HE ATTO HHG source, but also the complete MIR-HE ATTO beamline, including the experimental end-station for cutting-edge attosecond spectroscopy techniques. First experiments are planned in 2023 in joint collaboration with ELI ALPS.
Class 5 Photonics will be present at the "Nonlinear Optics" topical meeting by OSA.
An international forum for discussion of all aspects of nonlinear optics, including new phenomena, novel devices, advanced materials and applications. Join our Scientific talk about our Moonlander HHG source:
Class 5 Photonics moved to a new office and lab space. We are very happy to be now at the Start-Up Labs Bahrenfeld (slb.hamburg) just next to the DESY campus. The new office and lab space will allow us to grow even further and is a perfect enviornment for young high-tech companies. Our new address is: Luruper Hauptstraße 1, 22547 Hamburg. You can access our building from Luruper Hauptstraße (Bus line 3/X3/2, station »Stadionstraße«) or from the DESY campus for deliveries (building 98, Notkestr 85, 22607 Hamburg).
Rapp OptoElectronic and Class 5 Photonics make the next step in commercial systems enabling
three-photon microscopy for deep brain imaging. Joint measurements have been supported by the renowned University Medical Center Hamburg-Eppendorf (UKE) and show promising results in comparison to standard two-photon microscopy. 
Two-photon image (2p) and three-photon image (3p) of the dentate gyrus region in the hippocampus of a mouse. Depth 500 μm. Measurements are the result of a joint campaign of Rapp OptoElectronic and Class 5 Photonics in Hamburg with sample preparation provided by the University Medical Center Hamburg-Eppendorf (UKE).
We present the latest updates about our ultrafast, high-power laser technology at the CLEO virtual conference organized by OSA (Optical Society of America). From bio-imaging to time-resolved studies and CEP - there is something for everyone.
Join us on Thursday May 13th 2021 to see our contributions:
Another White Dwarf for 3-photon microscopy was installed in a bio-imaging lab in Germany. With > 5 W and 40 fs at 1300 nm the WD-1300 provides the highest average power and peak intensity on the market for advanced microscopy applications.
Additionally, our one-box solution and robust engineering achieves excellent power stability and pulse-to-pulse stability (typically < 0.5 %). The integrated, industrial Coherent Monaco 60 W pump laser provides additional reliability and user friendly operation of the White Dwarf system. Hence, biologists can focus on their in-vivo experiments while keeping laser maintenance to a minimum and increasing up-time. The installed system is upgradable with a second channel at 1700 nm (WD-1300-dual). An independent, second OPCPA channel is optimized at 1700 nm and hence multi-color experiments are possible when running the system in a parallel mode (1300 and 1700 nm simultaneously). Alternatively, the user can switch between 1300 and 1700 nm to double the average power at each wavelength for deep brain imaging.
Our CTO Michael presented at Photonics West 2021 our high-power OPCPA system for in vivo multi-photon microscopy: White Dwarf OPCPA. The White Dwarf OPCPA is a compact and robust laser system especially designed for multi-photon microscopy at high performance parameters.
Publication: High power OPCPA system for in-vivo 2- and 3-photon brain imaging, Proc. SPIE 11648, Multiphoton Microscopy in the Biomedical Sciences XXI, 1164819 (5 March 2021); doi: 10.1117/12.2578713 |
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